MORELIA, Mexico ? A Mexican military official says thousands of additional troops are being sent to the violence-stricken western state of Michoacan.
The official tells The Associated Press that some 4,000 soldiers have begun arriving in the state capital to prepare for an offensive in a mountainous western section of the state known as Tierra-Caliente. The area has been hit by a surge in violence in recent weeks.
The official spoke on condition of anonymity because he was not authorized to release the information. A military spokesman declined to comment.
Authorities in Michoacan are battling quasi-religious drug cartels called La Familia and the Knights Templar that claim to be following divine will.
Brandi Glanvilleisn't shy about her feelings that the adage "once a cheater always a cheater" applies to her ex-husband Eddie Cibrian. The Real Housewives of Beverly Hills star has gone on record warning LeAnn Rimes, who had an affair with Cibrian before the two got divorces and married each other, should know he could do it to her too.
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It is obvious that the Elderly Care is the excellent and unsurpassed option to care for the seniors. Everyone wants to keep their seniors always protected, happy and secure, but due to lack of time and busy schedule they are not able to do that. Elder care is like a care of a little child. They are not able to do the certain activities of their daily schedule. Dementia is a common disease that occurs in the people with the age and elders mostly suffer from this problem. So they require regular medical check-up and care. Aged people become weak and prone to fall at their old age. In such situation, you need to know the safety tips and instructions and to pursue them to frustrate mishaps and accidents.
The care of the aged is difficult for family members and due to such reason; most of the families go with the hiring of someone to care for their relatives. The most effective and inexpensive choice to care for your seniors or aged relatives and you can get services for your elderly parents or relatives without moving them from their usual place. You should make the accurate adjustment for your loved ones, if you want that their remaining days will spend well and fine.
If, you provide home care for your loved ones, especially when you are too far away, it can be something to respect what you have. The massive benefit in this is having your own loved ones taken care of your own home or in their home environment. There are several agencies and service organizations which help you in providing the best care and required services for your loved ones. They will provide guarantee for their work and trust. These provide basic need such as vigorous and healthy meals, medical services, washing, dressing the oldest and make sure that the work, cleaning, to be visited in their homes. In these organizations, the care provider is also there to provide personal care like staying with the elderly when the family is out the house; break care; financial management assisting on bill payments and medical services, etc. Home care occupies more than just checking on an older person. These bring a sense of security to our seniors that they are being taken care of in a known environment. They feel there like they are at their home. The care providers love them like a family member.
Author name is Ramandeep Kaur. She loves to share her views. Now she is sharing information on Elderly Care.
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An online information systems school teaches university students for positions in systems analysis, computer programming, and tech support. Distance schooling institution training programs impart the high level technological knowledge that Information systems industry experts need to facilitate computer-related duties in organization.
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Singapore scientists lead in 3D mapping of human genome to help understand human diseasesPublic release date: 1-Feb-2012 [ | E-mail | Share ]
Contact: Winnie Lim (Ms) limcp2@gis.a-star.edu.sg 65-680-88013 Agency for Science, Technology and Research (A*STAR), Singapore
Genome Institute of Singapore's (GIS) Associate Director of Genomic Technologies, Dr Yijun RUAN, led a continuing study on the human genome spatial/structural configuration, revealing how genes interact/communicate and influence each other, even when they are located far away from each other. This discovery is crucial in understanding how human genes work together, and will re-write textbooks on how transcription regulation and coordination takes place in human cells.
The discovery was published in Cell, on 19 January 2012. The GIS is a research institute under the umbrella of the Agency for Science, Technology and Research (A*STAR).
Using a genomic technology invented by Dr Ruan and his team, called ChIA-PET, the Singapore-led international group, which is part of the ENCODE (ENCyclopedia Of DNA Elements) consortium, uncovered some of the fundamental mechanisms that regulate the gene expression in human cells.
"Scientists have always tried to understand how the large number of genes in an organism is regulated and coordinated to carry out the genetic programs encoded in the genome for cellular functions in our cells. It had been viewed that genes in higher organisms were individually expressed, while multiple related genes in low organisms like bacteria were arranged linearly together as operon [1] and transcribed in single unit," Dr Ruan explained. "The new findings in this study revealed that although genes in human genomes are located far away from each other, related genes are in fact organised through long-range chromatin interactions and higher-order chromosomal conformations. This suggests a topological basis akin to the bacteria operon system for coordinated transcription regulation. This topological mechanism for transcription regulation and coordination also provides insights to understand genetic elements that are involved in human diseases."
GIS' executive director Prof Huck Hui NG said: "This is an important study that sheds light on the complex regulation of gene expression. Yijun's team continues to use the novel method of Chromatin Interaction Analysis with Paired-End-Tag sequencing to probe the higher order interactions of chromatin to discover new regulatory interactions between genes."
"This publication describes ground-breaking work by Dr Yijun Ruan and his team at Genome Institute o Singapore," added Dr Edward Rubin, Director of the Joint Genome Institute in US. "They address the fundamental question of how communication occurs between genes and their on and off switches in the human genome. Using a long range DNA mapping technology called ChIA-PET, the study reveals in three dimensional space that genes separated linearly by enormous distances in the human genome can come to lie next to each other in the cell when it is time for them to become active. I expect this study to move rapidly from primary scientific literature to textbooks describing for future students the operating principles of the human genome. The ChIA-PET technology, that is the telescope used in this exploration of the human genome, is an innovative and powerful molecular technology invented by Dr Ruan and his collaborators."
The ENCODE is an ongoing project which was awarded to Dr Ruan's team by the National Human Genome Research Institute (NHGRI), an institute belonging to the National Institutes of Health (NIH, USA). The project was set up in 2003 with the aim of discovering all functional elements in the human genome to gain a deeper understanding of human biology and develop new strategies for preventing and treating diseases. So far Dr Ruan's team has received over US$2 million towards this project.
###
Notes to the Editor:
Research publication:
The research findings described in the press release can be found in the 19 January 2011 advanced online issue of Cell under the title "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation".
Authors:
Guoliang Li,1,10 Xiaoan Ruan,1,10 Raymond K. Auerbach,2,10 Kuljeet Singh Sandhu,1,10 Meizhen Zheng,1 Ping Wang,1 Huay Mei Poh,1 Yufen Goh,1 Joanne Lim,1 Jingyao Zhang,1 Hui Shan Sim,1 Su Qin Peh,1 Fabianus Hendriyan Mulawadi,1 Chin Thing Ong,1 Yuriy L. Orlov,1 Shuzhen Hong,1 Zhizhuo Zhang,3 Steve Landt,4 Debasish Raha,4 Ghia Euskirchen,4 Chia-Lin Wei,1 Weihong Ge,5 Huaien Wang,6 Carrie Davis,6 Katherine Fisher,7 Ali Mortazavi,7 Mark Gerstein,2 Thomas Gingeras,6 Barbara Wold,7 Yi Sun,5 Melissa J. Fullwood,1 Edwin Cheung,1,8 Edison Liu,1 Wing-Kin Sung,1,3
Michael Snyder,4,* and Yijun Ruan1,9,*
1. Genome Institute of Singapore, 138672, Singapore
2. Program in Computational Biology and Departments of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
3. Department of Computer Science, School of Computing, National University of Singapore, 117417, Singapore
4. Center for Genomics and Personalized Medicine, Department of Genetics, Stanford University, Stanford, CA 94305, USA
5. Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA
6. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11797, USA
7. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
8. School of Biological Sciences, Nanyang Technological University, Singapore 637551
9. College of Life Sciences, Huazhong Agricultural University, Wuhan 430070, China
10. These authors contributed equally to this work
Winnie Lim (Ms)
Genome Institute of Singapore
Office of Corporate Communications
Tel: 65-6808-8013
Email: limcp2@gis.a-star.edu.sg
About the Genome Institute of Singapore
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science, Technology and Research (A*STAR). It has a global vision that seeks to use genomic sciences to improve public health and public prosperity. Established in 2001 as a centre for genomic discovery, the GIS will pursue the integration of technology, genetics and biology towards the goal of individualized medicine.
The key research areas at the GIS include Systems Biology, Stem Cell & Developmental Biology, Cancer Biology & Pharmacology, Human Genetics, Infectious Diseases, Genomic Technologies, and Computational & Mathematical Biology. The genomics infrastructure at the GIS is utilized to train new scientific talent, to function as a bridge for academic and industrial research, and to explore scientific questions of high impact. http://www.gis.a-star.edu.sg
About the Agency for Science, Technology and Research (A*STAR)
The Agency for Science, Technology and Research (A*STAR) is the lead agency for fostering world-class scientific research and talent for a vibrant knowledge-based and innovation-driven Singapore. A*STAR oversees 14 biomedical sciences and physical sciences and engineering research institutes, and six consortia & centres, located in Biopolis and Fusionopolis as well as their immediate vicinity.
A*STAR supports Singapore's key economic clusters by providing intellectual, human and industrial capital to its partners in industry. It also supports extramural research in the universities, and with other local and international partners. http://www.a-star.edu.sg
[1] In genetics, an operon is a functioning unit of genomic DNA containing a cluster of genes under the control of a single regulatory signal or promoter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Singapore scientists lead in 3D mapping of human genome to help understand human diseasesPublic release date: 1-Feb-2012 [ | E-mail | Share ]
Contact: Winnie Lim (Ms) limcp2@gis.a-star.edu.sg 65-680-88013 Agency for Science, Technology and Research (A*STAR), Singapore
Genome Institute of Singapore's (GIS) Associate Director of Genomic Technologies, Dr Yijun RUAN, led a continuing study on the human genome spatial/structural configuration, revealing how genes interact/communicate and influence each other, even when they are located far away from each other. This discovery is crucial in understanding how human genes work together, and will re-write textbooks on how transcription regulation and coordination takes place in human cells.
The discovery was published in Cell, on 19 January 2012. The GIS is a research institute under the umbrella of the Agency for Science, Technology and Research (A*STAR).
Using a genomic technology invented by Dr Ruan and his team, called ChIA-PET, the Singapore-led international group, which is part of the ENCODE (ENCyclopedia Of DNA Elements) consortium, uncovered some of the fundamental mechanisms that regulate the gene expression in human cells.
"Scientists have always tried to understand how the large number of genes in an organism is regulated and coordinated to carry out the genetic programs encoded in the genome for cellular functions in our cells. It had been viewed that genes in higher organisms were individually expressed, while multiple related genes in low organisms like bacteria were arranged linearly together as operon [1] and transcribed in single unit," Dr Ruan explained. "The new findings in this study revealed that although genes in human genomes are located far away from each other, related genes are in fact organised through long-range chromatin interactions and higher-order chromosomal conformations. This suggests a topological basis akin to the bacteria operon system for coordinated transcription regulation. This topological mechanism for transcription regulation and coordination also provides insights to understand genetic elements that are involved in human diseases."
GIS' executive director Prof Huck Hui NG said: "This is an important study that sheds light on the complex regulation of gene expression. Yijun's team continues to use the novel method of Chromatin Interaction Analysis with Paired-End-Tag sequencing to probe the higher order interactions of chromatin to discover new regulatory interactions between genes."
"This publication describes ground-breaking work by Dr Yijun Ruan and his team at Genome Institute o Singapore," added Dr Edward Rubin, Director of the Joint Genome Institute in US. "They address the fundamental question of how communication occurs between genes and their on and off switches in the human genome. Using a long range DNA mapping technology called ChIA-PET, the study reveals in three dimensional space that genes separated linearly by enormous distances in the human genome can come to lie next to each other in the cell when it is time for them to become active. I expect this study to move rapidly from primary scientific literature to textbooks describing for future students the operating principles of the human genome. The ChIA-PET technology, that is the telescope used in this exploration of the human genome, is an innovative and powerful molecular technology invented by Dr Ruan and his collaborators."
The ENCODE is an ongoing project which was awarded to Dr Ruan's team by the National Human Genome Research Institute (NHGRI), an institute belonging to the National Institutes of Health (NIH, USA). The project was set up in 2003 with the aim of discovering all functional elements in the human genome to gain a deeper understanding of human biology and develop new strategies for preventing and treating diseases. So far Dr Ruan's team has received over US$2 million towards this project.
###
Notes to the Editor:
Research publication:
The research findings described in the press release can be found in the 19 January 2011 advanced online issue of Cell under the title "Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation".
Authors:
Guoliang Li,1,10 Xiaoan Ruan,1,10 Raymond K. Auerbach,2,10 Kuljeet Singh Sandhu,1,10 Meizhen Zheng,1 Ping Wang,1 Huay Mei Poh,1 Yufen Goh,1 Joanne Lim,1 Jingyao Zhang,1 Hui Shan Sim,1 Su Qin Peh,1 Fabianus Hendriyan Mulawadi,1 Chin Thing Ong,1 Yuriy L. Orlov,1 Shuzhen Hong,1 Zhizhuo Zhang,3 Steve Landt,4 Debasish Raha,4 Ghia Euskirchen,4 Chia-Lin Wei,1 Weihong Ge,5 Huaien Wang,6 Carrie Davis,6 Katherine Fisher,7 Ali Mortazavi,7 Mark Gerstein,2 Thomas Gingeras,6 Barbara Wold,7 Yi Sun,5 Melissa J. Fullwood,1 Edwin Cheung,1,8 Edison Liu,1 Wing-Kin Sung,1,3
Michael Snyder,4,* and Yijun Ruan1,9,*
1. Genome Institute of Singapore, 138672, Singapore
2. Program in Computational Biology and Departments of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
3. Department of Computer Science, School of Computing, National University of Singapore, 117417, Singapore
4. Center for Genomics and Personalized Medicine, Department of Genetics, Stanford University, Stanford, CA 94305, USA
5. Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA
6. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11797, USA
7. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
8. School of Biological Sciences, Nanyang Technological University, Singapore 637551
9. College of Life Sciences, Huazhong Agricultural University, Wuhan 430070, China
10. These authors contributed equally to this work
Winnie Lim (Ms)
Genome Institute of Singapore
Office of Corporate Communications
Tel: 65-6808-8013
Email: limcp2@gis.a-star.edu.sg
About the Genome Institute of Singapore
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science, Technology and Research (A*STAR). It has a global vision that seeks to use genomic sciences to improve public health and public prosperity. Established in 2001 as a centre for genomic discovery, the GIS will pursue the integration of technology, genetics and biology towards the goal of individualized medicine.
The key research areas at the GIS include Systems Biology, Stem Cell & Developmental Biology, Cancer Biology & Pharmacology, Human Genetics, Infectious Diseases, Genomic Technologies, and Computational & Mathematical Biology. The genomics infrastructure at the GIS is utilized to train new scientific talent, to function as a bridge for academic and industrial research, and to explore scientific questions of high impact. http://www.gis.a-star.edu.sg
About the Agency for Science, Technology and Research (A*STAR)
The Agency for Science, Technology and Research (A*STAR) is the lead agency for fostering world-class scientific research and talent for a vibrant knowledge-based and innovation-driven Singapore. A*STAR oversees 14 biomedical sciences and physical sciences and engineering research institutes, and six consortia & centres, located in Biopolis and Fusionopolis as well as their immediate vicinity.
A*STAR supports Singapore's key economic clusters by providing intellectual, human and industrial capital to its partners in industry. It also supports extramural research in the universities, and with other local and international partners. http://www.a-star.edu.sg
[1] In genetics, an operon is a functioning unit of genomic DNA containing a cluster of genes under the control of a single regulatory signal or promoter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
WASHINGTON (AP) ? Get ready to find out who the millionaires are behind this year's presidential election.
Shadowy outside groups funded by anonymous donors and working on behalf of candidates they support have pummeled Mitt Romney, Newt Gingrich and others for the past two months by spending millions of dollars on mostly negative TV ads that have had an enormous impact on the fight for the Republican presidential nomination.
Now, for the first time since they started shaping this campaign in earnest, many of those "super" political action committees are set to disclose just who is financing their pseudo-campaign operations. Many took advantage of a change in federal rules that essentially let them shield their donors' identities until after key primary elections in January. But they still must submit their financial reports to the Federal Election Commission by Tuesday.
Only a handful of donors are known, including Las Vegas billionaire casino owner Sheldon Adelson. His two checks for $5 million apiece to Winning Our Future, a pro-Gingrich group, essentially kept the former House speaker's White House campaign afloat at critical junctures just before the South Carolina and Florida primaries.
Bain Capital executives and Romney friends have lined the bank accounts of the pro-Romney group Restore Our Future. Former Bain executive Edward Conrad donated $1 million last spring and Marriott International Inc. CEO J.W. Marriott Jr. gave the group $500,000, seed money spent to successfully hammer Gingrich in Iowa late last year as he started to rise.
That's when the super PACs sprang into action in full force.
Since then, groups working on behalf of Republican candidates for president have spent roughly $25 million in TV ads, most of which have been negative, in the first four states to vote in the GOP nomination battle ? Iowa, New Hampshire, South Carolina and Florida.
Of that, the pro-Romney Restore Our Future has spent about $14 million on ads, mostly to take down Gingrich in Iowa and Florida. That's more than the roughly $12 million Romney himself has spent on TV ads.
The super PACs have also unleashed millions on expenses typically reserved for campaigns, including direct mailings, phone calls and get-out-the-vote efforts.
It's a precursor to the general election, when super PACs aligned with both Republicans and President Barack Obama are planning to dole out even larger sums.
These groups are the products of a 2010 Supreme Court ruling that stripped away old restrictions on corporate and union spending in federal elections. They can't directly coordinate with the candidates they support, but many are staffed with former campaign workers who have an intimate knowledge of their favored candidate's strategy.
Some donors will never be known because some super PACs have established not-for-profit arms that can shield contributors' identities. Those arms can spend more than roughly half of their money on so-called advocacy, although campaign-finance reformers have urged the Internal Revenue Service to reduce that share.
Super PACs like American Crossroads ? backed by George W. Bush political adviser Karl Rove ? and its own nonprofit arm played a significant role in the 2010 midterm elections, helping deliver the House to the GOP and boost the number of Republicans in the Senate.
Tuesday's filings to the FEC won't just reveal many of the committees' financial backers; they'll also show how their money is being spent, particularly on infrastructure, payroll and travel. The same will be true in the campaign financial filings for President Barack Obama, Romney, Gingrich and others, who last released their finances in October 2011.
But, above all, the FEC filings are likely to show the awesome impact super PACs have in supplementing expansive, national campaigns.
Super PACs have become headaches for campaign-finance watchdogs, who have long warned of a potentially corruptive influence that hasn't been seen since the days of Watergate.
But some GOP-leaning groups say their ads contribute to a marketplace of ideas and counterbalance the huge sums of cash that Obama and the Democratic National Committee plan to spend on the president's re-election bid.
By law, presidential campaigns can raise, at most, $5,000 total from an individual donor.
But super PACs can solicit and spend unlimited money ? and some employ affiliated groups, known as 501(c)4 organizations, whose donors are allowed to remain anonymous. Watchdog groups like Democracy 21 have complained to federal regulators on that front, asking the IRS to limit how much those nonprofit groups can spend on political advocacy.
____
Follow Jack Gillum at http://twitter.com/jackgillum